Synthesis and characterization of the pain-killing peptide grammostola spatulata analgesic factor (GsAF-1) containing three disulfide bonds

摘要

Recent work at AstraZeneca resulted in the discovery of novel pain-killing peptides from the venom of the Chilean pink tarantula.These peptides,designated Grammostola spatulata analgesic factors (GsAF),were found effective in a variety of animal models of moderate-to-severe pain.They were also found to exhibit activity in models of neuropathic pain,and as such represent a potentially interesting approach to the amelioration of pain associated with cancer and the post-operative surgical period.