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3D models for conformational states of the V3 and V1/V2 loops in gp120/CD4/antibody complex

机译：V3和V1 / V2循环的构象状态的3D模型，GP120 / CD4 /抗体复合物

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The X-ray structure of the ternary complex of an engineered "core" gp120,CD4 and antibody does not contain the hypervariable V3 and V1/V2 loops (the gp120_(298-331) and gap 120_(126-196) fragments,respectively).These loops are extremely important in HIV function.We have restored several feasible 3D structures of these loops in gp120 applying a computational approach based on residue-residue contact matrices.

机译：工程化的“核心”GP120，CD4和抗体的三元复合物的X射线结构不含高变V3和V1 / V2环（GP120_（298-331）和GAP 120_（126-196）片段）。这些循环在艾滋病毒函数中非常重要。我们在GP120中恢复了几个可行的3D结构，其基于残留物残留矩阵施加计算方法。

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《the International Peptide Symposium》|2001年||共2页
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Stan Galaktionov; Gregory V.Nikiforovich; Garland R.Marshall;
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1. Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies. [J] . Mondor I, Moulard M, Ugolini S, Virology . 1998,第2期

机译：HIV gp120，CD4和CXCR4之间的相互作用：依赖CD4表达水平，gp120病毒起源，gp120 COOH-和NH2-末端以及V1 / V2和V3环的保守性以及对中和抗体的敏感性。
2. Antibody to the gp120 V1/V2 Loops and CD4(+) and CD8(+) T Cell Responses in Protection from SIVmac251 Vaginal Acquisition and Persistent Viremia [J] . Gordon Shari N., Doster Melvin N., Kines Rhonda C., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2014,第12期

机译：gp120 V1 / V2环和CD4（+）和CD8（+）T细胞反应的抗体可预防SIVmac251阴道习性和持续性病毒血症
3. Induced fit in HIV-neutralizing antibody complexes: Evidence for alternative conformations of the gp120 V3 loop and the molecular basis for broad neutralization [J] . Rosen O, Chill J, Sharon M, Biochemistry . 2005,第19期

机译：诱导适合HIV中和抗体复合物：gp120 V3环的替代构象的证据以及广泛中和的分子基础
4. 3D models for conformational states of the V3 and V1/V2 loops in gp120/CD4/antibody complex [C] . Stan Galaktionov, Gregory V.Nikiforovich, Garland R.Marshall the International Peptide Symposium . 2001

机译：V3和V1 / V2循环的构象状态的3D模型，GP120 / CD4 /抗体复合物
5. Studies of Protein Interactions and Knowledge-Based Drug Design: (A) The Electrostatic Nature of Recognition Between HIV-1 gp120 V3 Loop and Coreceptors CCR5/CXCR4, (B) Complement System Inhibition by Compstatin Family Peptides [D] . Lopez de Victoria Suarez, Aliana 2012

机译：蛋白质相互作用和基于知识的药物设计的研究：（A）HIV-1 gp120 V3环与共受体CCR5 / CXCR4之间识别的静电性质，（B）坎普他汀家族肽对补体系统的抑制作用
6. A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1 V2 and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12 [O] . Michael B. Zwick, Robert Kelleher, Richard Jensen, 2003

机译：一种新型的针对人类免疫缺陷病毒1型gp120的新型人类抗体是V1V2和V3环依赖性的有助于界定广泛中和的抗体免疫球蛋白G1 b12的表位
7. Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies. [O] . Mondor, I, Moulard, M, Ugolini, S, 1998

机译：HIV gp120，CD4和CXCR4之间的相互作用：依赖CD4表达水平，gp120病毒起源，gp120 COOH-和NH2-末端以及V1 / V2和V3环的保守性以及对中和抗体的敏感性。
8. Multiscale Modeling of Complex Systems Conformational Transitions in Proteins; Final rept. 15 Sep 2004-14 Oct 2006 [R] . Beck, T., Wijesekera, N., Rogers, D., 2006

机译：复杂系统的多尺度建模蛋白质中的构象转换;最终的评论。 2004年9月15日至2006年10月14日

3D models for conformational states of the V3 and V1/V2 loops in gp120/CD4/antibody complex

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