Cyclic octapeptide inhibitors of the acetylcholinesterase peripheral site:implications for inhibition of nerve toxins

摘要

The primary physiological role of acetylcholinesterase (AChE) is to hydrolyze the neurotransmitter acetylcholine at cholingergic synapses.AChE is among the most efficient enzymes,with a turnover number of >10~4 s~(-1).