High-density compound arrays of combinatorial chemical libraries by a new pen-directed and computer-navigated plotter device

摘要

The search for new drugs and synthetic vaccines by screening the vast diversity of chemical structures is one of the most challenging goals of modern synthetic chemistry and molecular biology.While nature uses the three-dimensional structures of linear sequences of amino acids in peptides and proteins in nearly all the life processes,chemistry makes in principle assessible the whole structural space of chemical compounds and artificial protein architectures.