A novel method to identify chemical compounds of combinatorial libraries by the use of paramagnetic tags [German]

摘要

An EPR method to identify non-destructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications is discribed. During synthesis chemical inert paramagnetic substances can be attached in small amounts to a solid-phase-synthesis resin for tagging of organic compounds or even reaction steps. The identification of single members of a combinatorial library in short time and high sensitivity can be carried out by using an EPR-spectrometer. [References: 28]