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METHOD OF MAKING AND USING CHEMICAL ARRAYS AND COMBINATORIAL LIBRARIES ON OPTICAL FIBERS
METHOD OF MAKING AND USING CHEMICAL ARRAYS AND COMBINATORIAL LIBRARIES ON OPTICAL FIBERS
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机译:在光纤上制造和使用化学阵列和组合库的方法
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摘要
A method has been developed which utilizes functionalized optical fibers as a solid support for the assembly of combinatorial libraries of compounds. The optical fibers are used to direct light, heat or a combination thereof to the compounds tethered to the fibers surface. Utilizing the method of the instant invention reactions occurring by both photochemically and thermally allowed pathways are accessible. In a preferred embodiment of the invention, the optical fibers are used to screen the array by fluorescence spectroscopy of labeled target molecules which bind to the immobilized library compounds.
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