Variation in ring size of cyclic antimicrobial peptides results in diversity and selectivity of biological activity

摘要

In continuing our efforts to understand the structure-function relationships in the cationic cyclic antimicrobial peptides [e.g.,1,2],the ring size was varied from 10 to 16 amino acids in the a series of cyclic peptides based on the structure of GS10 (a decameric analog of the antimicrobial peptide gramicidin S) to study the effect of changes in peptide size,structure,hydrophobicity and amphipathicity on biological activity.