A new strategy for inverse solid-phase peptide synthesis

摘要

Solid-phase peptide synthesis (SPPS) in the N-to-C direction (inverse SPPS [1-4]) provides the synthetically versatile peptide C-terminal carboxyl group for further modifications,which is particularly useful in synthesis of C-terminally modified peptide mimetics.As part of our ongoing program to find peptide mimetic protease and penicillin-binding protein inhibitors,a strategy for inverse SPPS based on amino acid t-butyl esters has been developed.