Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—OH (I)comprising:(a) reacting an immobilized compound of formula (II):Sub-(L)-[N(R1)-A-C(O)]p—[NH-A-C(O)]n—OH (II)with an amino acid ester or peptide derivative of formula (III):H—[NH-A-C(O)]m—O(tBu) (III)in the presence of a coupling agent to yield a peptide compound of general formula (IV):Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—O(tBu); (IV)(b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I);wherein n is a positive integer, e.g., 1–10, preferably 1–5; m is a positive integer, and P is 0–1."/>
Attachment and elaboration strategies for inverse peptide synthesis
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Attachment and elaboration strategies for inverse peptide synthesis
Attachment and elaboration strategies for inverse peptide synthesis
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机译:逆肽合成的附着和精细化策略
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摘要
The present invention provides a process for preparing a peptide of formula I):Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—OH (I)comprising:(a) reacting an immobilized compound of formula (II):Sub-(L)-[N(R1)-A-C(O)]p—[NH-A-C(O)]n—OH (II)with an amino acid ester or peptide derivative of formula (III):H—[NH-A-C(O)]m—O(tBu) (III)in the presence of a coupling agent to yield a peptide compound of general formula (IV):Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—O(tBu); (IV)(b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I);wherein n is a positive integer, e.g., 1–10, preferably 1–5; m is a positive integer, and P is 0–1.展开▼
机译:本发明提供了制备式I)的肽的方法:<?in-line-formulae description =“ In-line Formulae” end =“ lead”?> Sub- [L]-[N(R 1 Sup>)-AC(O)] p Sub>-[NH-AC(O)] n + m Sub> -OH(I)<?in-line-formulae description =“在线表达式” end =“ tail”? > 包含: ListItem> (a)使固定化的式(II)化合物反应:<?in-line-formulae description =“ In-line Formulae” end =“ lead”?> Sub-(L)-[N(R 1 Sup>)-AC(O)] p Sub>-[NH-AC(O)] n Sub> -OH(II)<?in-line-formulae description =“ In-line Formulae” end =“ tail”?> < UnorderedList id =“ ul0003” listStyle =“ none”> 与式(III)的氨基酸酯或肽衍生物:<?in-line-formulae description =“在线公式” end =“ lead”?> H- [NH-AC(O)] m Sub> -O(tBu)(III)<? inline-formulae description =“ In-line Formulae” end =“ tail”?> ListItem> 在偶联剂存在下产生肽的过程中通式(IV)的化合物:<?in-line-formulae description =“ In-line Formulae” end =“ lead”?> Sub- [L]-[N(R 1 Sup>)-AC(O)] p Sub>-[NH-AC(O)] n + m Sub> -O(tBu); (IV)<?in-line-formulae description =“ In-line Formulae” end =“ tail”?> ListItem> UnorderedList> ListItem> UnorderedList> ListItem> UnorderedList>
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