Pathologic Effects of Clinical Uterine Inflammation on the Equine Endometrial Mucosa

摘要

Chronic uterine infection or persistent inflammation in the mare is associated with hypersecretion of mucus and disruption of the architecture of the endometrial epithelium. Mucolytic agents, administration of steroids, or prolonged sexual rest may beneeded to restore endometrial function. The reproductive tract is similar to the respiratory tract in that both have mucosal immune systems and may produce excessive quantities of mucus if persistently irritated. Excessive mucus may interfere with penetration of intrauterine antibiotics, sperm motility, and embryo migration, resulting in subfertility. Previous work indicates that mucus secretion increases during experimental uterine inflammation and in mares with delayed uterine clearance.