The cornified cell envelope (CE), formed by transglutaminase mediated epsilon -( gamma -glutamyl) lysine cross-linking of specialised proteins is the most insoluble component of the terminally differentiated keratinocyte. Under normal Nomarski optics two types of CE are readily distinguishable: an irregularly shaped, readily deformed "fragile" envelope (CEf) which predominates in the deepest layers of the skin, and a polygonal "resilient" or "rigid" envelope (CEr) which represents over 80
展开▼
