The cornified cell envelope:an important marker of stratum corneum maturation in healthy and dry skin

摘要

The cornified cell envelope(CE) formed by transglutaminase-mediated epsilon-(gamma-glutamyl)lysine cross-linking of specialized corneocyte proteins is the most insolube component of the terminally differentiatedkeratinocyte.Under normal Nomarski optics,two types of CE are readily idstinguishable:an irregularly shaped,readily deformed 'fragile'envelope(CEf),which predominates in the deepest layers of the stratum corneum,and a polygonal "resilient"or 'rigid'envelope(CEr),which represents over 80% of the CE population in the superficial layers.