Involvement of transglutaminase in ex vivo maturation of cornified envelopes in the stratum corneum

摘要

The cornified envelope (CE) is a thin insoluble structure enveloping corneocytes,and is essential for the barrier function of the stratum corneum (SC).Our previous studies revealed that immature CEs are detected in the outermost layer of SC of barrier-impaired epidermis including the face and in various inflammatory disorders,using a non-invasive method to evaluate CE maturity.However,factors attributable for immaturity of CEs are still unclear.The aim of the present study is to clarify whether immature CEs in the SC have the potential to mature.