Dual-mode stress and mass measurements with chemical and biochemical microcantilever sensor arrays

摘要

In this work, we present dual-mode measurements of chemical and biochemical microcantilever sensor arrays. Multiple microcantilevers are monitored simultaneously in our homemade nanomechanical analyzer. A single stationary optical beam is used to read bending of the microcantilevers and to record their thermal noise. Added mass is calculated from measured thermal noise resonance frequency shift and surface stress is assessed based on static bending. We present experimental data on self-assembling monolayers growth, receptors immobilization, and target molecule detection on microcantilevers. Crosstalk between both measurement modes is possible. We show experimental proofs for such crosstalk and discuss its nature.