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Integrins and infections

机译:整合和感染

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摘要

Integrins are a large family of heterodimeric receptors (consisting of an #alpha# and a #beta# chain) that mediate cell-cell and cell-extracellular matrix (ECM) recognition in nearly all cells. Many #alpha# and #beta# chains have been discovered, and most #beta# chains can associate with more than one #alpha# chain, creating a large repertoire of at least 22 receptor combinations. Integrins interact with the actin cytoskeleton via talin, #alpha#-actinin and vinculin and, thus, represent a mechanismfor plasma membrane-cytoskeleton association. The integrins expressed in leukocytes, their expression pattern, and ligand specificity have been reviewed(1). The #beta#_2 family of integrins are expressed exclusively on leukocytes and are a major class of integrins involved in regulating effector functions in lymphocytes and phagocytes. Integrins have the ability to mediate activation, adhesion, migration, and phagocytosis by interacting with ligands experessed in their environment. Cellular and matrixprotein ligands are primarily found in inflamed tissues, allowing leukocytes to sense an inflammatory locus.
机译:整联蛋白是一个大族杂项异二聚体受体(由#α#和#β#链组成),其在几乎所有细胞中介导细胞 - 细胞和细胞 - 细胞外基质(ECM)识别。已经发现了许多#alpha#和#beta#链条,大多数#beta#链可以与多个#alpha#链相关联,创建至少22个受体组合的大型曲目。整联蛋白通过Talin,#α# - actinin和vinculin与肌动蛋白细胞骨架相互作用,因此代表了血浆膜 - 细胞骨架组合的机制。已审查(1)中以白细胞,表达模式和配体特异性表达的整年蛋白。 #β#_2系列整合蛋白在白细胞上表达,是一种主要的整体整合素,参与淋巴细胞和吞噬细胞中的效应功能。整联蛋白能够通过与环境中经验的配体相互作用来介导活化,粘附,迁移和吞噬作用。细胞和基质蛋白配体主要在发炎组织中发现,允许白细胞感测炎性基因座。

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