Optical coherence elastography as a new method for estimation of chemotherapy efficacy on triple-negative breast cancer in the experiment

摘要

Normal and pathological tissues are different in their elastic properties. Thus, elastic characteristics of tissues can serveas an additional diagnostic marker to distinguish altered tissues. A number of studies have demonstrated advantages ofusing optical coherent tomography in clinical practice and research. Here we report the application of optical coherenceelastography (OCE) for studying elastic properties of murine breast cancer 4T1. It is known that 4T1 model isconvenient for in vivo tumor imaging and is highly relevant to studies of tumor process. In this study the therapy wasperformed with a cytostatic chemotherapeutic drug cisplatin. We developed the protocol of compressional OCTelastography for long-term in vivo monitoring of tumor response to anti-tumor therapy. The ear tumor model was chosenas optimal for this task. Histological analysis demonstrated good agreement with OCE-based stiffness-mapping results.