PAS-MUT with Somatic Mutations in Cancer and Classified Diseases for Clinical-Genomics Research: PAS-MUT Somatic Mutations

摘要

Over the recent years, enormous progress has been made in mapping complex traits in humans. These studies have demonstrated that there is a crucial need to generate appropriate gene-disease annotation repositories accessed through modern resources. Our focus here is to create a comprehensive database with mobile access to authentic somatic mutations in cancer and classified diseases worldwide, considered as the foundation for clinical and genomics research, epidemiology and precision medicine. In this manuscript, we present a non-commercial, academic and publically available iOS app i.e., PAS-MUT, which invites global users to freely download it on iPhone & iPad devices, quickly adopt its easy to use interface and search for somatic mutations, genes and related diseases. PAS-MUT is developed with Swift multi-paradigm programming language, XCODE integrated development environment for MacOS, and PHP scripting that uses MySQL database and web servers. PAS-MUT database includes over a million authentic somatic mutations released global, including available at the COSMIC, CNVD, SwissVar, and ClinVar etc. PAS-MUT is founded on the clinical and scientific premise to support and promote healthcare and genomics data sharing with technological advancements.