EFFECTS OF INHALATION TRANSIENCE ON PARTICLE TRANSPORT THROUGH A CT-BASED HUMAN AIRWAY GEOMETRY

摘要

The effects of inhalation transience on particle transport through the lungs were examined using numerical simulation. Physiologically appropriate, regional ventilation was induced through a computed tomography (CT) based human airway geometry for steady and transient inhalation using lobar-specific boundary conditions. Transient inhalation and the analogous steady cases were simulated for two breathing rates. Particle transport was modeled for a range of particle sizes and Stokes numbers. The deposition fractions of particles were analyzed and comparisons were made between the results for steady and transient inhalation. Deposition fractions for particles released during transient inhalation were substantially less than those released during steady inhalation for all but the largest particle sizes. Future work is suggested.