Evaluating Protein Sequence Signatures Inferred from Protein-Protein Interaction Data by Gene Ontology Annotations

摘要

We propose a systematic method to find sequence signatures of proteins which share a common interacting partner,using a protein similarity measure based on gene ontology(GO) annotations. In a computational experiment on our original human data set of protein-protein interactions determined by Y2H assays, we have succeeded in discovering convincing candidates for interacting sites and other functional regions.