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Dielectric Properties of Water Solutions with Small Content of Glucose in the Millimeter Wave Band and the Determination of Glucose in Blood

机译:毫米波段葡萄糖含量的水溶液介电性能及血液中葡萄糖的测定

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The dielectric properties of 0.9% NaC1 in water with small content of sugar and glucose, as well as of human skin, were measured in the millimeter (MM) waves range. The measurement methods were chosen so that one could use them for the nondestructive control of glucose content (i.e., measurement only reflection of an electromagnetic wave, without penetrating into the medium). To determine ε' and ε", of lossy materials one usually measures the power reflection coefficient and the phase of the reflected wave with the help of sophisticated and expensive network vector analyzers. We developed a sufficiently simple method and scheme, which consists in measuring the minimum of the power reflection coefficient R(f) = R_(min)(f_(min)) and its frequency f_(min) in the cases of corresponding to this minimum from the following structures: a specially chosen plane-parallel matching plate made of a low-loss dielectric or resonator - a medium under measurement with high losses (solution, blood, skin). This method was realized in the MM waves range. Dielectric properties of glucose solutions in water and in a 0.9% NaCl solution (physiological solution) have been measured. Also was measured dielectric properties os human skin. The values of ε' and ε" have been measured near the elbow joint in the frequency range from 30 to 80 GHz. Above 40 GHz, these data have been obtained for the first time, whereas, at frequencies of 30-40 GHz, the values of ε" obtained in our experiments are higher than those available in the literature. Our method allows a real-time noninvasive determination of glucose content in blood by measuring reflection on skin. We established a clear correlation between glucose content W and the measured value of reflection coefficient as W increases after an oral glucose tolerance test (OGTT) on an empty stomach. The functions R_(min)(W) show similar but individual behavior for each test person. It was established a correlation between glucose content Wafter OGTT and the properties of skin. The results of the measurements described can be used to implement real-time, including noninvasive, measurements of small glucose (sugar) content in water, physiological solution, and blood.
机译:在毫米(MM)波范围内测量含有少量糖和葡萄糖含量小的0.9%NaC1在水中的介电性能,以及人体皮肤。选择测量方法,使得可以使用它们来用于葡萄糖含量的非破坏性控制(即,仅测量电磁波的反射,而不渗透到介质中)。为了确定ε'和ε“,借助于复杂和昂贵的网络矢量分析仪,通常测量电力反射系数和反射波的相位。我们开发了一种充分简单的方法和方案,包括测量功率反射系数R(F)= R_(min)(F_(min))及其频率f_(min)在与下列结构相对应的情况下:特殊选择的平面平行匹配板低损耗电介质或谐振器 - 具有高损失(溶液,血液,皮肤)测量的介质。该方法在MM波范围内实现。水中葡萄糖溶液和0.9%NaCl溶液中的介电性质(生理学)已经测量了溶液。还测量了介电性质OS人体皮肤。ε'和ε“的值已经在肘关节的频率范围内测量为30至80 GHz。在40 GHz以上,这些数据首次获得,而在30-40GHz的频率下,我们的实验中获得的ε“的值高于文献中可用的值。我们的方法允许实时非侵入性通过测量皮肤反射测定血液中的葡萄糖含量。我们在空腹口腔葡萄糖耐量试验(OGTT)后的反射系数与反射系数的测量值之间的明显相关性。功能R_(min )(w)显示每个测试人员的类似但个人行为。它建立了葡萄糖含量呈葡萄糖含量与皮肤的性质之间的相关性。所描述的测量结果可用于实施实时,包括非侵入性,包括非侵入性测量水,生理溶液和血液中的小葡萄糖(糖)含量。

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