A COMPARISON OF THROMBUS SUSCEPTIBILITY FOR TWO PULSATILE 50 CC LEFT VENTRICULAR ASSIST PUMPS

摘要

The TSP calculation is not the sole indicator of thrombus potential for a given device. Risk factors for deposition include: the local fluid mechanics, properties of the blood, and properties of the blood contacting surface. The TSP is a reasonable means of analysis as the blood contacting sac material is the same for all Perm State LVADs. Additionally, patients are typically administered similar anticoagulants. This leaves local fluid mechanics as the variable. The effects of shear rate and exposure time are currently being studied through platelet adhesion studies to more accurately define them for use with the sac material. Results of this work are currently being used to validate computational fluid dynamic modeling of the Perm State 50 cc LVAD designs.