Design, synthesis and biological activity evaluation of novel antibacterial agent (E)-1-(4-chlorobenzyl)-5-styrylindoline-2, 3-dione

摘要

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization, N-Alkylation, Microwave-asistant Heck coupling reaction and so on. Among those compounds, (E)-1-(4-chlorobenzyl)-5-styryl-indoline-2-carbonyl-3, 3-(ethylenedioxy) dione and (E)-1-(4-chlorob-enzyl)-5-styrylindoline-2, 3-dione possess novel structures and have not been reported before. Five newly synthesized compounds were characterized on the basis of 1H NMR, 13C NMR and mass spectra, and those compounds were tested for their biological activities against Gram+ and Gram− bacteria. Among those compounds, (E)-1-(4-chlorobenzyl)-5-styrylindoline-2, 3-dione demonstrated good antibacterial activity against Escherichia coli (Gram−) and moderate antibacterial activity against Staphyloccocus aureus (Gram+).