The effect of Simvastatin Acid Loaded Photocurable Hyaluronic Acid Hydrogel for Bone Regeneration in vitro and in vivo

摘要

Introduction: Therapeutic repair of skeletal tissues has received significant interest by the scientific community. Advances in reconstructive orthopaedic surgery, such as total hip replacement, spinal fusion and plastic surgery, resulting from progress in surgical procedures and the increase in an ageing population, have lead to a demand for bone grafts that exceeds the current available supply. Therefore, the loss of bone tissue due to congenital defects, trauma and following tumor resection represents a major clinical problem [South-Paul JE 2001, Percival M 1999]. Bone regeneration has been an important issue for millions of patients worldwide who have suffered from bone disease or defect, such as osteosacoma, osteoporosis, bone fracture, and etc. Regeneration of bone tissues is among the most promising area of biological repair that has the potential of providing a broad spectrum of potential clinical applications. Recently, bone tissue engineering, an interdisciplinary field at the intersection of engineering, biology and medicine, has emerged as one of approaches to develop biological bone substitute that restore, maintain or imorove bone tissue function.