Noninvasive glucose monitoring in vivo based on Monte Carlo modeling

摘要

Non-invasive glucose monitoring is one of the most active areas in biomedical research. A novel method for blood glucose measurement is presented. The measuring system consists of modulated laser, polarizer, photodiode and the lock-in amplifier. To study the light propagation and distribution in skin, the tissues model is established by using Monte Carlo Method. The results demonstrate that linear relationship between concentration of glucose in the range of physiological level and rotation degree of polarized light. The measurement system utilize balanced detector reduces the intensity noise originating from the laser, The technique, makes possible a direct measurement of a component of the Stokes vector and, most importantly fits measurements on the tissue by using near-infrared laser. On the whole, the optical heterodyne polarimeter technique proved to be an efficient tool for the study of glucose-induced changes in blood and tissue phantoms in vitro.