Reconstruction of 3D radial distribution of interphase chromatin in lymphocyte nucleus for various diseases

摘要

The wavelet tomography is used for statistical reconstruction of a lymphocyte nucleus for various diseases. The restored parameter is a probability density function (PDF) of radial distribution of condensed chromatin. In this content, PDF describes the cross-section of the nuclear structure of chromatin. Initial dat for reconstruction is the histogram of the chromatin granules, i.e. the number of granules versus the distance for the center of projection. This work is concerned with lymphocyte nuclei of peripheral blood for four groups of patients: control group; those who live in the area affected by the Chernobyl accident; mieloid group; leucose group. In contrast to the previous work, the new criteria of regularization is developed and used.