Peroral sustained-release of drugs showing solubility and biological-related shortcomings

机译：药物的口服持续释放显示出溶解性和生物学相关的缺点

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The development of sustained-release oral dosage forms requires the knowledge of the physico-chemical and pharmacokinetic properties of the active substance, especially the solubility at the physiological pHs and the absorption rate and extent at the different sections of the gastrointestinal (GI) tract.

机译：缓释口服剂型的发展需要了解活性物质的物理化学和药代动力学性质，尤其是在生理pH中的溶解度和胃肠道（GI）道不同部分的吸收率和程度。

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《International symposium on controlled release of bioactive materials;Consumer and diversified products conference 》|1998年|p.808-809|共2页
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K. Amighi; A.J. Moes;
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中图分类基础医学 ;
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1. Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. II. Bioavailability and tolerance assessment in dogs. [J] . Timmermans J, Amighi K, Puigdevall J, Drug development and industrial pharmacy . 1998 ,第6期

机译：经口缓释膜包衣的小丸可作为克服物理化学和生物药物相关问题的手段。二。狗的生物利用度和耐受性评估。
2. Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. II. Bioavailability and tolerance assessment in dogs. [J] . Timmermans J, Amighi K, Puigdevall J, Drug development and industrial pharmacy . 1998 ,第6期

机译：经口缓释膜包衣的小丸可作为克服物理化学和生物药物相关问题的手段。二。狗的生物利用度和耐受性评估。
3. Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. I. In vitro development and evaluation. [J] . Amighi K, Timmermans J, Puigdevall J, Drug development and industrial pharmacy . 1998 ,第6期

机译：Peroral缓释膜涂层颗粒作为克服物理化学和生物药物相关问题的手段。 I.体外发展和评估。
4. Peroral sustained-release of drugs showing solubility and biological-related shortcomings [C] . K. Amighi, A.J. Moes International symposium on controlled release of bioactive materials . 1998

机译：Peroral持续释放药物显示溶解度和生物学相关的缺点
5. Controlling drug delivery for the application of extended or sustained-release drug products for parenteral administration. [D] . O'Neil, Jacklyn. 2010

机译：控制药物的递送，以用于肠胃外给药的缓释或缓释药物产品的应用。
6. Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles [O] . Prachi B. Shekhawat, Varsha B. Pokharkar 2017

机译：了解经口吸收：解决溶解性和渗透性障碍的法规方面和当代方法
7. Drug product development and pharmacological evaluation of a sparingly soluble novel camptothecin analog for peroral administration [O] . Vijaykumar Nekkanti, Pradeep Karatgi, Srinivasarao Paruchuri, 2011

机译：药物产品开发和药理学评估对令人遗憾的新型喜树碱类似物的组织局

Peroral sustained-release of drugs showing solubility and biological-related shortcomings

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