PROBLEM TO BE SOLVED: To provide a liquid sustained-release suspension dosage form comprising an ionized form of water-soluble drugs.;SOLUTION: There is provided a liquid-form controlled-release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix. The surface charge of the ion-exchange matrix is opposite to that of the electrolytic drug. The dispersed phase further comprises a non-electrolytic soluble component having a low molecular weight, a diffusion controlling membrane and a dispersion medium substantially free of diffusible counter ions, and further comprises an excipient capable of associating with water and impeding water activity. Accordingly, drug dissolution is inhibited prior to administration. There are also provided a method for preparation of the composition and a treating method.;COPYRIGHT: (C)2013,JPO&INPIT
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