Effect of cod-liver oil extract on the buccal permeation of ergotamine tartrate

摘要

Ergotamine tartrate (ET) is used clinically in the treatment of migraines. However ET has a large molecular weight (MW. 1313) and the bioavailability of ET is rather poor following oral administration. Therefore, we tried to improve ET delivery using buccal administration. However, the buccal permeation rate was usually in the range of one or more orders of magnitude lower than those found for other mucosal sites, in particular the nasal mucosa.