Membrane proteins (MPs) are important for drug design and have been targeted by approximately half of current therapeutic drugs. In many genomes 20-40% of genes encode MPs. In particular, Human genome has >5,000 reviewed MPs and more than 3000 of them are non-redundant at 25% sequence identity. Experimental determination of MP structures is challenging as they are often too large for NMR experiments and very difficult to crystallize. As of October 2016, there are ~ 510 non-redundant MPs with solved structures, and a majority number of MPs have no solved structures.
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