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In-vivo Biocompatibility and Toxicity of Single Walled Carbon Nanotube Composites for Bone Tissue Engineering

机译:骨组织工程用单壁碳纳米管复合材料的体内生物相容性和毒性

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Biodegradable composites are or interest in clinical medicine because of their biocompatibility, bioresorbability, non-immunogenicity, and high mechanical strength, essentially circumventing the need to surgically remove the implanted scaffold. SWCNT/PLAGA composites are ideal for BTE. We demonstrated in our previous published and unpublished studies that incorporation of SWCNT to PLAGA significantly enhances cell proliferation and mechanical strength. The results obtained from this study will demonstrate the potential of SWCNT/PLAGA composites for musculoskeletal regeneration and will offer a novel substitute for BTE. Future studies will be designed to evaluate the efficacy of SWCNT/PLAGA composites in bone regeneration in a rabbit model. As interest in carbon nanotube technology increases, studies must be performed to fully evaluate these novel materials at a nonclinical level to assess their safety. The ability to produce composites capable of promoting bone growth will have a significant impact on tissue regeneration and will allow greater functional recovery in injured patients.
机译:可生物降解的复合材料因其生物相容性,生物再吸收性,非免疫原性和高机械强度而在临床医学中引起人们的兴趣,实质上避免了通过外科手术去除植入支架的需要。 SWCNT / PLAGA复合材料非常适合BTE。我们在先前已发表和未发表的研究中证明,将SWCNT掺入PLAGA可显着增强细胞增殖和机械强度。从这项研究中获得的结果将证明SWCNT / PLAGA复合材料在肌肉骨骼再生方面的潜力,并将为BTE提供新的替代品。将设计进一步的研究,以评估SWCNT / PLAGA复合材料在兔模型中的骨再生中的功效。随着对碳纳米管技术的兴趣增加,必须进行研究以在非临床水平上全面评估这些新型材料,以评估其安全性。生产能够促进骨骼生长的复合材料的能力将对组织再生产生重大影响,并使受伤患者的功能恢复更大。

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