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In-vivo Biocompatibility and Toxicity of Single Walled Carbon Nanotube Composites for Bone Tissue Engineering

机译:单壁碳纳米管复合材料骨组织工程的体内生物相容性和毒性

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Biodegradable composites are or interest in clinical medicine because of their biocompatibility, bioresorbability, non-immunogenicity, and high mechanical strength, essentially circumventing the need to surgically remove the implanted scaffold. SWCNT/PLAGA composites are ideal for BTE. We demonstrated in our previous published and unpublished studies that incorporation of SWCNT to PLAGA significantly enhances cell proliferation and mechanical strength. The results obtained from this study will demonstrate the potential of SWCNT/PLAGA composites for musculoskeletal regeneration and will offer a novel substitute for BTE. Future studies will be designed to evaluate the efficacy of SWCNT/PLAGA composites in bone regeneration in a rabbit model. As interest in carbon nanotube technology increases, studies must be performed to fully evaluate these novel materials at a nonclinical level to assess their safety. The ability to produce composites capable of promoting bone growth will have a significant impact on tissue regeneration and will allow greater functional recovery in injured patients.
机译:可生物降解的复合材料是临床医学的兴趣,因为它们的生物相容性,生物吸血鬼,非免疫原性和高机械强度,基本上是避难的需要手术去除植入的支架。 SWCNT / Plaga复合材料非常适合BTE。我们在我们以前的发布和未发表的研究中证明,将SWCNT纳入PLAGA显着提高了细胞增殖和机械强度。本研究获得的结果将证明SWCNT / Plaga复合材料的潜力用于肌肉骨骼再生,并将提供新的BTE替代品。将来将设计未来的研究来评估SWCNT / PLAGA复合材料在兔模型中骨再生中的功效。随着对碳纳米管技术的兴趣增加,必须进行研究以在非纯度水平上充分评估这些新材料以评估其安全性。生产能够促进骨生长的复合材料的能力将对组织再生产生显着影响,并将在受伤患者中允许更大的功能恢复。

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