A Comparative Study of Disease Genes and Drug Targets in the Human Protein Interactome

摘要

Most complex diseases are caused by variation in many genes, which are defined as disease genes. Medicines (drugs) are major choices to treat the diseases or reduce their symptoms as they act through interacting with some proteins. These proteins are defined as drug targets. Thus, disease genes contribute to the pathology of one disease while drug targets are critical for the efficacy of disease treatment. However, the interrelationship between the disease genes and drug targets is not clear.