POTENTIAL TARGET FOR AN IMMUNOTHERAPEUTIC APPROACH TO STOP PARKINSON'S DISEASE IN HUMANS: CDNA AND PROTEIN STRUCTURE FOR A PUTATIVE ACTIVATOR OF HUMAN DOPAMINE RECEPTOR AND HUMAN BRAIN CA2+ CHANNEL PROTEIN RECONSTRUCTED FROM THE ANTISENSE STRAND OF THE HUMAN APP GENE

摘要

A cDNA reconstructed from the antisense strand of human APP gene encodes a 224 amino acid (aa) protein "Cadrac", which contains a 25 aa domain that is capable of interacting with the human dopamine receptor and the human brain Ca2+ channel protein. Both dopamine and Ca2+ signalling are likely to be involved in Parkinson's disease. The human APP gene is involved in Alzheimer's disease and there is an established relationship between Alzheimer's disease and Parkinson's disease. Since `Cadrac' cannot be expressed in healthy humans the protein is potentially a good candidate for an immunotherapeutic approach to stop Parkinson's disease in humans.