Adjuvant Free Peptide Nanofibers Elicit CD8~+ T Cell Responses after Intranasal Administration

摘要

Conclusions: Peptide nanofibers elicited strong antigen specific CD8~+ T cell responses without any adjuvants. They were capable of stimulate high numbers of CD8~+ T cells in the lung when challenged with the PR8 virus. These results demonstrate supramolecular peptide nanofibers have the potential to be engineered as safe and effective mucosal and CD8~+ T cell vaccines.