Long Term Survival of PEGylated Murine Allogenic Islets using Short Course Immunomodulation

摘要

Islet PEGylation represents a simple, highly cell compatible procedure to modulate the graft microenvironment and improve allogeneic islet transplant survival. In combination with short-course immunotherapy, murine allograft rejection can be prevented in a large majority of the transplants. This study demonstrates the synergy of the combinatorial use of these strategies. Mechanistic data remains to be evaluated to fully characterize the mechanism of this effect. This work is the first step towards the development of methods for bioactive modification of graft surfaces to attain succesful immunomodulation in the local microenvironment.