Animal Model of Open Femur-Fracture Infection Using Noninvasive In Vivo Bioluminescence Imaging

摘要

(1) We established an open femur fracture infection model using bioluminescent S. aureus, which allowed the determination of S. aureus distribution in the fracture model. (2) Bioluminescence was used to detect active bacterial colonies and the in vivo signals in Group B peaked at post-operative days 7 to 10. (3) Noninvasive bioluminescence imaging may have the potential to monitor infection in animal models for long-term study. However, challenges exist.