POLY(GLYCEROL SEBACATE) FILMS MODIFIED BY THERMAL PROTEINS FOR CARDIAC TISSUE ENGINEERING

摘要

Scaffolds for cardiac tissue engineering must be designedto achieve adequate degradation kinetics and mechanicalproperties. In this study, bulk modification ofpoly(glycerol sebacate) (PGS) with differentconcentrations of thermal proteins (TP) was investigatedto tailor the degradation properties of PGS. TP are polyaminoacids formed by heating a mixture of amino acidswith minimal proportions of glutamic or aspartic acid.The degradation study of TP-PGS was performed in vitroin phosphate buffered saline (PBS) solution over a 21 dayperiod. Results showed that the degradation rate of PGSincreased with increasing content of TP. After 21 days inPBS, degradation weight loss values of 9.40% ± 0.07,7.3% ± 0.8 and 6.0% ± 0.4 were determined for PGS-TP-2g, PGS-TP-0.01g and PGS-control, respectively. Thestudies also showed that TP altered the mechanicalproperties and surface hydrophilicity of PGS.