Roles of RORα on Transcriptional Expressions in the Mammalian Circadian Regulatory System

摘要

REV-ERBα and RORα are involved in the molecular regulatory system of mammalian circadian cycles, expressing opposite interactions on Bmal1 expression, inhibition and activation, respectively. REV-ERBα has been thought to be the major regulator of gene expressions in phases, which is more than the role of RORα. This paper gives a contrary result to this, showing a prominent role of RORα in determining phase relations of the gene expression cycles. Computer simulations are conducted for the predictions of this RORα role, in addition, one of these predictions is supported by a biological experiment that shows combinatory effect of RORα and CRY on Bmal1 transcription.