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Breast Cancer-specific Delivery of Therapeutic microRNA with Novel Breast Cancer-targeting Cell Penetrating Peptide-conjugated Gene Carrier

机译:新型靶向乳腺癌的细胞穿透肽偶联基因载体与治疗性microRNA的乳腺癌特异性递送。

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The microRNA-145 was delivered with BCSP-bPEI carrier and reduction of migration, proliferation, invasion of breast cancer cells in vitro was observed. BCSP-bPEI-miR-145 was injected to xenograft mouse models of breast cancer and demonstrated the suppression of malignant breast tumor.
机译:microRNA-145与BCSP-bPEI载体一起递送,观察到体外乳腺癌细胞的迁移,增殖和侵袭减少。 BCSP-bPEI-miR-145被注射到乳腺癌的异种移植小鼠模型中,并证明了其对恶性乳腺肿瘤的抑制作用。

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