Identification of a Novel Functional Domain of Ricin Responsible for Its Potent Toxicity

摘要

Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate the universally conserved α-sarcin loop of large rRNAs.They have received attention in biological and biomedical research because of their unique biological activities toward animals and human cells as cell-kilting agents.A better understanding of the depurination mechanism of RIPs could allow us to develop potent neutralizing antibodies and to design efficient immunotoxins for clinical use.