首页> 外文会议>Annual meeting of the Society for Biomaterials >Effect of Transforming Growth Factor -betal (TGF-pl) on human vocal fold fibroblasts in 3-DimensionaI (3-D) hyaluronan hydrogel environment
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Effect of Transforming Growth Factor -betal (TGF-pl) on human vocal fold fibroblasts in 3-DimensionaI (3-D) hyaluronan hydrogel environment

机译:在3维(3D)透明质酸水凝胶环境中转化生长因子-壁(TGF-pl)对人声带成纤维细胞的影响

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In order to understand how hyaluronan hydrogel promotes vocal fold wound healing and how biological activity affects subsequent cell behavior, we have investigated hVFFs in 3-D Carbylan-GSX in response to TGF-pl. Carbylan-GSX inhibited TGF-pi-induced myofibroblast differentiation and up-regulated MMPs expression, increased MMPs to TIMP3 ratios, (indicate) ECM degradation and remodeling. This study suggests that after vocal fold injury, locally injected Carbylan-GSX can promote the structure and function recovery of the vocal fold. Further work will focus on the mechanism of Carbylan-GSX affects cell behaviors, including MSCs differentiation and signal transduction.
机译:为了了解透明质酸水凝胶如何促进声带伤口愈合以及生物活性如何影响随后的细胞行为,我们研究了3-D Carbylan-GSX中针对TGF-β1的hVFF。 Carbylan-GSX抑制TGF-pi诱导的成肌纤维细胞分化,并上调MMPs表达,增加MMP与TIMP3的比例,(表明)ECM降解和重塑。这项研究表明,声带损伤后,局部注射Carbylan-GSX可以促进声带的结构和功能恢复。进一步的工作将集中在Carbylan-GSX影响细胞行为的机制上,包括MSC分化和信号转导。

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