Previous studies have shown that optical clearing techniques have great potential for optical diagnosis and therapy. In order to further discuss the effect by different drug delivery method, diffusion chambers were used to simulate in vivo physiological environment; and the optical clearing agents were acted on the surface of porcine skin, the saline was contacted with the dermal side (epidermal application). Then they were compared with the traditional method-samples immersed in the optical clearing agents (mainly dermal immersion). The transmission intensity of skin was monitored by an integrating sphere system. The changes in thickness were measured before and after experiments. The results showed that the optical clearing effect and die changes in thickness are not coincident under the two different methods. It indicates that the optical clearing effect and mechanism may relate to the drug delivery method.
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