Intraperitoneal delivery of Chitosan/siRNA nanoparticles targeting TNF-α prevents radiationinducedfibrosis

摘要

This work describes intraperitoneal delivery ofchitosan/siRNA nanoparticles targeting TNF-α asprevention for radiation-induced fibrosis. CDF1 micetreated with TNF-α siRNA at least until day 22 afterradiation did not develop fibrosis whereas the controlgroups treated either with buffer or mismatch siRNAdevelop severe fibrosis.Altogether, nanoparticles-mediated TNF-αknockdown in peritoneal macrophages presents a novelstrategy for radiation-induced fibrosis.