Adjustment of Desired Drug Release Patterns From Pellets Coated With Aqueous Ethylcellulose Dispersions: Importance of the Type of Core and Drug Solubility

摘要

The addition of varying amounts of PVA-PEG-graft-copolymer to ethylcellulose-based coatings provided a wide range of stable release profiles from theophylline-loaded beads, without flocculating the coating dispersion. The present study demonstrates that this approach is applicable also to freely water-soluble drugs.