A Surfactant-based Glass Thermoplastic System (GTS) for Formulating Poorly Water- Soluble Weak Base Drug Candidates

机译：一种基于表面活性剂的玻璃热塑性系统（GTS），用于配制较差的水溶性弱碱药物候选物

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摘要

A novel glass thermoplastic system (GTS) containing a pharmaceutically acceptable surfactant, a water-soluble organic acid (such as citric acid), hydroxypropylmethylcellulose (HPMC) and the drug to be solubilized is described.

机译：描述了含有药学上可接受的表面活性剂的新型玻璃热塑性系统（GTS），水溶性有机酸（例如柠檬酸），羟丙基甲基纤维素（HPMC）和待溶解的药物。

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《Controlled Release Society Annual Meeting and Exposition》|2007年||共2页
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Roger Vandecruys; Geert Verreck; Jef Peeters; M. Brewster;
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中图分类生物工程学（生物技术）;
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1. A Novel Cyclodextrin-containing Glass Thermoplastic System(GTS)for Formulating poorly Water soluble Drug Candidates:Perclinical and Clinical Results [J] . Marcus E.Brewster, Roger Vandecruys, Geert Verreck, Journal of Inclusion Phenomena and Macrocyclic Chemistry . 2002,第1a4期

机译：用于配制水溶性较差的药物候选者的新型环糊精玻璃热塑性系统（GTS）：悬垂性和临床结果
2. Comparison across Three Hybrid Lipid-Based Drug Delivery Systems for Improving the Oral Absorption of the Poorly Water-Soluble Weak Base Cinnarizine [J] . Joyce Paul, Yasmin Rokhsana, Bhatt Achal, Molecular pharmaceutics . 2017,第11期

机译：跨三种杂交脂质的药物递送系统比较，用于改善水溶性弱碱粘液中的口腔吸收
3. Impact of mixed counter ion on saturation solubility of esylate salt of a weak basic drug to formulate physically stable and non-hemolytic ready to use injectable solution [J] . Dalwadi Gautam, Sun Yan, Wang Lihong, International Journal of Pharmaceutics . 2019,第期

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4. A Surfactant-based Glass Thermoplastic System (GTS) for Formulating Poorly Water- Soluble Weak Base Drug Candidates [C] . Roger Vandecruys, Geert Verreck, Jef Peeters, Controlled Release Society Annual Meeting and Exposition . 2007

机译：基于表面活性剂的玻璃热塑性体系（GTS），用于配制水溶性差的弱碱药物候选物
5. The evaluation of larch arabinogalactan as a new carrier in the formulation of solid dispersions of poorly water- soluble drugs. [D] . Thakare, Kalpana. 2013

机译：对落叶松阿拉伯半乳聚糖作为难溶性药物固体分散体制剂中新载体的评价。
6. Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery [O] . Bruno Fonseca-Santos, Aline Martins dos Santos, Camila Fernanda Rodero, 1988

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7. Formulating Buffered Dissolution Media for Sparingly Soluble Weak Acid and Weak Base Drug Compounds Based on Microenvironmental pHo Considerations [O] . Erika Stippler, Naiffer E. Romero, John W. Mauger 2014

机译：基于微环境PHO考虑，制定缓冲溶解培养基，用于静脉溶于弱酸和弱碱药物

A Surfactant-based Glass Thermoplastic System (GTS) for Formulating Poorly Water- Soluble Weak Base Drug Candidates

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