A Molecular Model of Biological Activity for Quinolone Compounds

摘要

Beginning with the research of the molecular structure of quinolone compounds, some new molecular topological indices and an ion-inhibition chromatography (IIC) for hydrophobic constants are proposed. The quantitative relationship between the molecular structures and the biological activities as well as hydrophobic constants for quinolone compounds are established. The introduction of artificial neural network into molecular structure has successfully predicted the biological activities of the new generation quinolone compounds such as Tosulfloxacin etc.