Effect of photodynamic therapy in intimal hyperplasia by phthalocyanine conjugated to the scavenger-receptor ligand maleylated bovine serum albumin

摘要

Initial hyperplasia is major cause of restenosis after vascular interventions for arterial occlusive disease. We reported that a fluorescent probe, Texas Red, conjugated to the scavenger-receptor ligand, maleylated bovine serum albumin accumulated almost exclusively in the injured, hyperplastic sites. The purpose of this study is to test the feasibility of enhanced drug delivery to the hyperplastic lesion by targeting the scavenger-receptors.