The impedance cardiography ambulatory monitoring device, which enables continuous collection of ECG and central hemodynamics signals, was applied for evaluation of hemodynamic variability in 5 male patients with atrial fibrillation (56-78 yr.) and in 5 (control) healthy males (44-68 yr.) during day time and night hours. The coefficient of variations (used as an index of variability) was higher in patients for stroke volume (by 0.203, p>0.05, 0.227/spl plusmn/0.19 vs. 0.43/spl plusmn/020), cardiac output (0.19, p>0.05, 0.16/spl plusmn/0.08 vs. 0.35/spl plusmn/19), amplitude (0.22, p>0.02, 0.17/spl plusmn/0.09 vs. 0.39/spl plusmn/0.15) and was not different for ejection time (ET: 0.19/spl plusmn/0.05 vs. 0.21/spl plusmn/0.05), pre-ejection period (PEP: 0.22/spl plusmn/0.06 vs. 0.24/spl plusmn/0.08). It was concluded that the variability of SV is mainly caused by the changes in amplitude of the signal and the variation in ET has the smaller impact.
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