In Silico Assessment of Nanosecond Pulse Exposures of Cells, Tissues and Organs

摘要

We have developed an in silico framework that integrates macro- and microdosimetry models, and incorporates biophysical mechanism models to estimate biochemical change resulting from exposure to nanosecond electrical pulses. This approach provides estimates of conductance changes and biochemical release/uptake within cells, local tissue regions and organs