The Role of Multiple Sequence Repeat Motifs in the Assembly of Multi-protein Complexes

摘要

Proteins incorporating multiple sequence repeats (for example ARM, HEAT, TPR, LRR and ankyrin) play critical roles in coordinating the assembly of multi-subunit complexes. This lecture will discuss the different types of protein architecture generated by successive copies of each repeat motif type and describe how these structures are suited to the formation of protein-protein interactions, allowing such proteins to function as scaffolding proteins in the assembly of multi-protein complexes.